There has been a fair amount of information regarding Anamorelin (also known as Anamorelin hydrochloride) going around recently. However, how much do we actually know about this growth hormone secretagogue receptor (GHS)?
You don’t have to scroll through the internet for long before you come across the supposed new big thing that is promising to boost weight loss, increase skeletal muscle mass, and total body mass. What we really want to know is, how does a GHS like Anamorelin even work? But also, how effective can they really be?
We’re going to cover everything from benefits to side effects and even a comparison of Anamorelin vs Ibutamoren.
Without further ado, let’s get stuck in.
What is Anamorelin?
Typically referred to as a more “buffed up” version of MK-677 (another popular SARM), Anamorelin is a synthetic ghrelin receptor agonist. It’s something that is very well known within bodybuilding circles because of its power to increase lean body mass.
Anamorelin stimulates growth hormone secretion and appetite by activating ghrelin receptors. You can therefore then expect an increase in body weight and lean body mass.
As is the case with all SARMs and supplements like Anamorelin, they were not originally developed for bodybuilders and athletes. They were created to treat muscle wasting diseases, congestive heart failure and other conditions. However, even for clinical uses, Anamorelin has its limits due to short half life.
As much as this novel oral ghrelin mimetic and growth hormone secretagogue receptor may be linked to an increase in lean body mass, there is also plenty more to unearth.
What was the original intention of Anamorelin?
So, much like anabolic steroids and other performance-enhancing drugs, Anamorelin benefits weren’t designed to be experienced by bodybuilders.
Instead, as we mentioned earlier, Anamorelin was originally developed to treat cachectic cancer patients and anorexia cachexia.
Also Read: THE 5 BEST NATURAL WAYS TO GROW MUSCLE
Cancer cachexia is a wasting syndrome characterized by weight loss, anorexia (often referred to as anorexia cachexia) asthenia and anemia.
Now, cancer cachexia occurs in many cancers, usually at a more advanced stage of the disease. Throughout clinical trials, Anamorelin showed to improve cancer cachexia by improving appetite and increasing serum insulin like growth factor-1.
Anamorelin and non small cell lung cancer
During clinical trials in Japan, which included placebo controlled studies, Anamorelin showed significant improvement in increasing lean body mass and strength in patients with advanced non small cell lung cancer and other types of cancer.
Anamorelin has shown that it increases lean body mass in non small cell lung cancer patients, as well as improving strength, although not handgrip.
Whilst in a clinical trial, Anamorelin has been shown to typically treat advanced cancer, such as non small cell lung cancer, its powers to increase body weight muscle mass have made it popular with bodybuilders and athletes alike.
Anamorelin: how does it work?
Even though Anamorelin has not been approved by the FDA for general use outside of a medical setting, it is an orally active, ghrelin receptor agonist, which stimulates growth hormone production.
As clinical trials have clearly shown that Anamorelin has a positive impact on growth hormone. But, not only that, Anamorelin can lead to the building of muscle proteins, therefore muscle mass, as well as increased strength and endurance.
Patients with advanced cancer have benefitted from its approved use in a medical scenario treating cancer anorexia cachexia syndrome.
Right, so when you’re using Anamorelin for bodybuilding, what can you expect?
In spite of the fact the original intention of Anamorelin hydrochloride was to treat cancer cachexia – which as we learned earlier, is a catabolic disorder – it then comes as absolutely no surprise that Anamorelin then found its way into bodybuilding circles.
In the treatment of cancer cachexia, cancer patients would experience extreme weakness, triggering other symptoms such as anorexia cachexia (often referred to as ‘cancer anorexia cachexia syndrome’), with a reduced food intake and weight loss.
Seeing as Anamorelin encourages growth hormone release, your appetite is then also increased. During clinical trials, Anamorelin showed to increase lean body mass, with a higher appetite increasing calorie intake in cancer patients, resulting in better metabolism and conversion process.
Whilst taking Anamorelin, it’s obstructing the process of muscle breakdown, cancer patients could also experience increased strength and stamina overall. This boost of growth hormone has made this GHS an incredibly popular alternative to steroids.
Here’s a list of Anamorelin benefits in relation to bodybuilding:
- Increased growth hormone levels
- Significant improvement of lean body mass
- Regulates metabolism
- Inhibits the process of muscle breakdown
- Helps build muscle proteins
- Enhanced strength
The importance of IGF-1
Insulin like growth factor (IGF-1) plays a really important role in the development of bones and tissues, by triggering the proliferation of stem cells. By enhancing the musculoskeletal system, IGF-1, alongside Anamorelin can improve athleticism.
Furthermore, elevated plasma levels of IGF-1 and insulin-like growth factor-binding protein 3 (IGFBP-3) can also help in glucose metabolism and regulating blood glucose levels.
What about Anamorelin vs Ibutamoren?
If you’re keen on achieving Anamorelin bodybuilding results, the chances are, you’ve come across Ibutamoren before now too. You may very well have heard it referred to as ‘MK-677’ too.
The truth is, Anamorelin works in the same way as MK-677, by mimicking the action of ghrelin and therefore encouraging the release of growth hormone (GH). However, whilst Ibutamoren has remained an experimental drug, Anamorelin has been approved…
But only for medical use.
This means that Anamorelin has been approved for treating cases such as anorexia cachexia and cancer related cachexia, helping cancer patients avoid muscle wasting and instead, build lean muscle mass. Ibutamoren (AKA, MK-677) is a selective androgen receptor modulator, otherwise known as a SARM.
SARMs still have a lack of clinical studies on humans and as a result of this, there is no patient reported symptom assessments so we are not able to draw any conclusions about its clinical effectiveness
Meanwhile, Anamorelin is a non-peptidic growth hormone secretagogue (GHS).
Anamorelin is often placed head to head in an Anamorelin vs Ipamorelin comparison as well. Ipamorelin is a growth hormone secretagogue (GHS), comprised of five amino acids. It works by minding to growth hormone secretagogue receptors (GHS-R1a), stimulating growth hormone release.
If we take a look at Anamorelin vs Ipamorelin, we can see that when compared, Anamorelin offers limited benefits. Whilst Ipamorelin has benefits that include quick healing, enhanced recovery, healthier musculoskeletal system and more.
Anamorelin dosage bodybuilding
So far, only oral forms of Anamorelin are available. These seem to have better bioavailability, triggering growth hormone release pretty efficiently.
Unlike many other growth hormone secretagogues (GHS), Anamorelin is one of few that appears to be effective in oral form.
So, what is the right Anamorelin dosage bodybuilding-wise?
Research and user anecdotal evidence suggests adults have as high as 100mg of daily intake of Anamorelin. If you prefer, you can split this dose in half and consume two tablets per day.
After reading clinical trials of Anamorelin and info about placebo treated patients, if you do decide to use this growth hormone secretagogue, it’s important you begin with a low dosage.
Experienced users recommend starting with 25 to 40mg at first. This allows your body to get used to it, before you then increase the dose to 50mg. After using Anamorelin for a little while, you could go up to 100mg as mentioned above.
Usually, an Anamorelin bodybuilding cycle would last up to 12 weeks.
Anamorelin bodybuilding results
So, what can you expect in terms of Anamorelin results?
Studies have shown that Anamorelin can significantly increase growth hormone levels at all doses. Alongside this, significant improvement in body weight was recorded, with these changes correlating with changes in IGF-1 levels.
The (small amount of) research showed that Anamorelin increases:
- Growth hormone
- Body weight
- Food intake
In cancer cachexia patient research, Anamorelin showed significant metabolic effects.
Anamorelin: the side effects
Working in the same way as MK-677, Anamorelin side effects are certainly worth noting. By mimicking the action of the hunger hormone ghrelin, it stimulates the ghrelin receptor, stimulating the release of growth hormone.
Of course, like MK-677, which has side effects such as:
- Resistance to insulin
- Increase in prolactin levels
- Painful joints
- Water retention
- Tingling in the hands and fingers
Also Read: THE NEWBIE’S GUIDE TO HYPERTROPHY
Here are some of the Anamorelin side effects mentioned by users:
The above may seem like pretty common side effects for most mediations. However, there are also more severe Anamorelin side effects relating to hyperglycemia (high blood sugar levels) and specific gastrointestinal disorders.
Is Anamorelin legal?
Anamorelin – when used as drug therapies for cancer cachexia patients has allowed it to be approved for human-based clinical trials. However, the FDA are yet to approve it for legal purchase.
Yep, that’s right. You’re only getting your hands on Anamorelin (legally) for research purposes. And before you say it, no, your need for muscle mass doesn’t quite count as research.
If you’re looking to compete in bodybuilding comps, getting your hands on Anamorelin hydrochloride is certainly a way to get yourself disqualified.
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Yes okay, an Anamorelin supplement may well increase your body weight and boost growth hormone (GH), but are any of those potential side effects worth it? Probably not
There’s a reason why Anamorelin has only been approved for use in medical settings and in treating patients with advanced non small cell lung cancer.
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