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Hexarelin HGH dosage, side effects and benefits

Hexarelin, also known as Examorelin and Hexarelin Acetate, is a synthetic hexapeptide known for enhancing human growth hormone (HGH) release.

At this point, we’re all pretty aware of the impact of HGH, right? However, if you’re not sure, let’s have a quick recap to make sure we’re all on the same page.

What is human growth hormone?

Human growth hormone, aka HGH, is produced naturally in the pituitary gland, which is somewhat of a master gland in our bodies and is responsible for many different bodily functions. HGH is particularly important during puberty and is what causes growth in children and teenagers. Growth hormone plays a pivotal role in growth and cell regeneration, whilst also being crucial to building, maintaining, and repairing healthy tissue in our organs and brain.

In a gym and bodybuilding setting, many men are looking for a way to boost their growth hormone levels so they can enhance their muscle growth and build muscle mass.

Similar to GHRP-6, Hexarelin has many of the same benefits and functions, however, it is believed to be even more potent, therefore increasing HGH levels even more.

How does Hexarelin work?

A synthetic growth hormone-releasing peptide (GHRP), Hexarelin acts via specific receptors in the pituitary gland and the hypothalamic level, stimulating growth hormone (GH).

Hexarelin is composed of a chain of amino acids, which trigger the production of growth hormones. Currently, the exact way that Hexarelin works in comparison to GHRP-6 is somewhat unknown, although it is shown to deliver strong results from its first use. However, further research is needed here.


As well as a Hexarelin dosage boosting human growth hormone levels, studies have shown that it can also increase prolactin and cortisol levels in the body. However, this can vary between different users, and the increase in prolactin has been shown to be not as significant as other anabolic steroids.

In addition, unlike GHRP-6, Hexarelin doesn’t appear to increase levels of ghrelin, despite their chemical composition being almost identical.

What does ‘growth hormone secretagogue’ mean?

 Growth hormone secretagogues (GHS) are non-natural peptidyl and non-peptidyl molecules, they work to increase growth hormone release, which encourages muscle growth. But further research is needed to better understand the effects of long-term administration of Hexarelin peptide and other growth hormone secretagogues (GHS).

Some Hexarelin benefits could include:

  • Growth velocity (in children)
  • Reduced bone turnover
  • Improved lean muscle growth.

What was Hexarelin peptide developed for?

Although the bodybuilding community has utilized Hexarelin for its muscle enhancement properties, it was actually originally created to treat health conditions such as growth hormone deficiency and congestive heart failure.

It was only during clinical trials that its ability to boost body strength, reduce body fat and enhance muscle growth was revealed. So, it’s no surprise that Hexarelin has found itself on the bodybuilding community’s radar. Similar to anabolic steroids, which now commonly feature in bodybuilding, was actually developed to treat muscle wasting conditions and types of anemia.

Cardiovascular health

When used in clinical trials, medical research on animals, Hexarelin was tested for its relation to cardiovascular health. When tested on rats, research revealed that their hearts were notably safe and the CPP values, or cerebral perfusion pressure, were in the range of the healthy rats from the beginning of the experiment.

Body composition and muscle growth

During a clinical trial on six beagles, Hexarelin peptide was shown to improve indices of body composition.

Hexarelin dosage

Typically, Hexarelin is administered 2-3 times a day at dosages of 100mcg per administration. Hexarelin is administered through a subcutaneous injection, usually to the stomach or abdomen. A Hexarelin dosage needs to be administered at least twice a day to increase growth hormone levels as much as possible during a cycle (up to 16 weeks).

Although Hexarelin can be used for anti-aging, it’s best suited for enhancing body composition and athletic performance.

Hexarelin half-life

Medical research revealed Hexarelin peptide affects plasma gh levels, peaking at about 30 minutes and then decreasing to baseline values within 240 minutes – with a half-life of around 55 minutes.

Hexarelin benefits

Although Hexarelin is considered to be one of the fastest-acting growth hormones on the market, it also stops working on the body after a certain amount of time has passed.

According to users, Hexarelin benefits include:

  • Increase in lean muscle growth
  • Improved sleep quality
  • Enhance athletic performance
  • Increased flexibility and joint health
  • Accelerated fat loss
  • Increased tendon and ligament strength
  • Enhanced recovery time

Of course, as with any substance, Hexarelin results can vary from one user to the next. The type of results you will experience during Hexarelin will also be influenced by your diet and exercise regime.

Due to its ability to increase lean muscle growth and strength gains, these benefits have led Hexarelin to grow in popularity with athletes looking to stay lean and improve their recovery time. It’s also important to note that Hexarelin isn’t ideal for long-term use.

Some of the best Hexarelin benefits include its healing and recovery properties, and plenty of data reports it to be the best growth hormone for this purpose.


Do the Hexarelin benefits come with potential side effects?

Although increased growth hormone levels can result in lean muscle mass growth, improved sleep and fat loss, growth hormone can increase the desire for sleep and make you feel tired.

Here are some common Hexarelin side effects:

  • Tiredness and lethargy
  • Excess Hexarelin dosage may lead to water retention
  • Tingling or numbers in the hands and feet
  • May have a stimulatory effect on adrenocorticotropic hormone (ACTH), cortisol, and prolactin

As with all anabolic steroids and growth hormone, the potential risk of Hexarelin side effects is very much real. While it seems like the benefits of Hexarelin are huge, the potential for negative side effects is higher than other human growth hormones.

Hexarelin side effects: Estrogenic side effects

The most common estrogenic side effect of Hexarelin is water retention. And while some users have reported being able to combat this with diet and exercise, there is potential for developing breast tissue, aka manboobs (or gynecomastia).

Androgenic side effects of Hexarelin use

Hexarelin doesn’t lead to androgenic side effects, for example, hair loss and acne, and virilization in women will not occur from the use of this peptide.

Cortisol level risks of Hexarelin administration

Hexarelin (a synthetic growth hormone) may lead to increased cortisol levels in the body. However, this can vary from user to user and will largely depend on the individual, as well as influence from any other hormones a user may be taking.

Those who are affected by an elevation of cortisol levels may suffer from symptoms such as:

  • Difficulty falling or staying asleep
  • An increase in fat gain
  • A lowering of their immune system
  • Lack of sexual desire
  • Depression and anxiety

GH secretion after Hexarelin

In studies of well-nourished 20-to-40-year-old HD patients, Hexarelin has shown to peak growth hormone levels. GH levels peaked at 30 min and remained elevated at 180 min.

Hexarelin bodybuilding – Is it worth it?

Hexarelin peptide is derived from GHRP-6 and is considered a selective agonist of the ghrelin receptor and/or growth hormone secretagogue receptor. And whilst Hexarelin has an influence on ghrelin, it doesn’t have a similar sequence and instead works to mimic ghrelin, acting as a ghrelin receptor.


Incredibly potent, Hexarelin peptide can help your body to produce more human growth hormone, stimulating lean muscle growth and boosting performance – but is it worth it?

We don’t think so.

With potential side effects like decreased libido, increased cortisol and prolactin levels, we’re not sure the benefits outweigh the side effects.

Is Hexarelin legal?

Although Hexarelin bodybuilding has become increasingly common, it is only legally used for research purposes and is not for recreational purposes. Currently, it’s not legal and hasn’t been deemed safe for human consumption (outside of a medical research setting).

Instead, we would recommend seeking a safe, legal alternative to Hexarelin peptide.

Is there a safe way to increase human growth hormone levels?

If you’re looking to increase growth hormone GH and without needing a subcutaneous injection, then you might want to give Hexarelin peptide a miss.

Here at Juiced Upp, we created ENDURO LEAN to mimic the effects of growth hormone. The strongest Hexarelin alternative on the market, you can experience performance-enhancing effects, increased muscle growth and enhanced HGH levels with ZERO side effects.

Yep! ENDURO LEAN is 100% natural, legal and has no need for injections or prescriptions.

Want to know what it takes to be the most confident guy in the room and have great skin? Well, you need to read this.

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