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How long does Cardarine take to work? (GW 50156)

After just 10 minutes at the gym, you’ll no doubt hear some dudes gossiping away to themselves about Cardarine – often referred to as ‘GW 50156’ and ‘GW 501516’. Whether it’s a debate on Cardarine kick in time, whether it works as a fat burner or really works to boost muscle gains, Cardarine is a hot topic in bodybuilding circles.

The chances are, you’ve half-listened to their conversation, curious as to whether this wonder drug really does work…

Don’t fret, we’ll be covering it all below, including:

  • How long does Cardarine take to work?
  • GW 50156 half-life
  • GF 50156 fat loss
  • What to expect when taking Cardarine

If your aim is to build lean muscle mass, you’ve most likely come across GW 50156 on your search to up your training. Whether you’re here to gain greater insight (for those discussions at the gym!), or seriously considering using it yourself, let’s dive in.

What is Cardarine GW 501516?

Although it is frequently marketed and sold as a SARM (selective androgen receptor modulator), Cardarin GW 50156 (GW 501516) is actually a PPAR Agonist.

But what the heck is that? Peroxisome proliferator-activated receptors (PPARs) are involved in the metabolic regulation of lipid and lipoprotein levels.

So far, ‘SARMs’ (although actually a PPAR Agonist) such as Cardarine have shown some positive results during animal testing, for treating metabolic diseases. During research, it has been shown to increase endurance during exercise quite significantly.

Of course, like many other SARMs/PPAR Agonists and bodybuilding steroids, these drugs have quickly found their way into the bodybuilding community. For Cardarine in particular, many dudes rave about its fat burning abilities, helping them to get lean muscle mass and appear shredded.


Before you go considering Cardarine the best fat burner on earth, it’s important to note that it has shown complications in the animals’ health during clinical trials. So much so, that it was deemed unsafe way back in 2007. This also means that GW 501516 has also been added to the prohibited compound list by WADA – so I wouldn’t expect to go competing while using Cardarine.

While it may pop up in a lot of gym discussions as though it came out yesterday, Cardarine GW 501516 isn’t new. It has actually been around for some time, and is often referred to as GW-XT SARM (AKA Cardarine GW 501516), as part of a collection of selective androgen receptor modulators (SARMs) used for muscle growth.

The debate of it being a SARM or PPAR Agonist is another topic completely!

What does Cardarine GW 501516 contain?

Cardarine GW 501516 is a synthetic substance not to be taken lightly. Made of monocarboxylic acid – most commonly known as Endurobol – is requires a consistent exercise regime in order to be digested properly.

While it goes without saying, it’s also crucial to stick to a healthy, balanced diet.

How does Cardarine GW 501516 work?

Much like many other bodybuilding SARMs, PPAR Agonists and steroids, Cardarine fat burner was originally intended to treat metabolic diseases and cardiovascular health. Instead, bodybuilders looking to GW 501516 for fat loss and its ability to help preserve lean muscle mass during a cutting cycle.

Cardarine GW 501516 works by looking to bind to PPARδ receptors, a group of proteins found in muscles and fatty acids in the body. When these receptors are activated, it encourages the body to burn fat, increase muscle endurance and boost lean muscle building.

Also Read: Top 4 Ways To Mentally Prepare For A Body Transformation

While on the topic of popular SARMs, Cardarine GW 501516 is often utilized as a stacking compound too, with many praising its abilities as a fat burner. Due to this, Cardarine GW 501516 has become popular with those looking to encourage fat loss and boost lean muscle mass.

What can you expect while using Cardarine GW 501516?

Here are the main results of Cardarine binding to the PPARδ receptor:

  • Increased oxidative capacity in muscles (which leads to a drop in body fat and increased endurance)
  • Cardarine works to switch your energy source from glucose to fat (suppression of glucose metabolism)

Where did Cardarine originate from?

During research into compounds that could increase fat burning, and therefore fat loss, as well as physical performance and endurance, research scientists were led down the PPAR-delta route.

This is where they came across the potential benefits of Cardarine GW 501516 and its impact on metabolic concerns associated with an inactive lifestyle, including:

  • High blood pressure
  • Diabetes
  • Increased inflammation
  • Cardiovascular health

Cardarine GW 501516 dosage

In order to maximize your use of Cardarine GW 501516, it’s imperative to understand the correct dosage information.

A quick look at any Cardarine review will talk about the right dosage for them. Typically, most users found the most effective Cardarine dosage to be between 10 and 20mg per day.

What’s the Cardarine kick in time like?

Users report the best time to take Cardarine GW 50156 around 1 to 2 hours before exercising. A Cardarine cycle length typically lasts anywhere between 4 and 12 weeks.

If your aim is fat loss, you may opt for between 10 and 20mg per day, while some go as little as 2.5mg per day.

With potential cancer risks, there is no ‘safe’ dosage.

How long does Cardarine take to work?

Even on a 10mg dosage, Cardarine kick in time can vary. Some reviews claim to feel the effects pretty much straight away, while others mention feeling the effects after 30 to 60 minutes.

So, what’s its primary usage?

Typically, Cardarine GW 50156 is used to reduce body fat. In many a Cardarine review, users claim to see fat loss results in as little as 10 to 14 days into their cycle. Alongside this, users taking Cardarine report that it increases endurance – with some even claiming to notice a difference in their workout performance within 30 minutes.

Also Read: How To Make Friends In The Gym

Cardarine GW 50156 half-life

With many users advising to dose GW 501516 once per day, its half life sits between 12 and 24 hours. This means that it remains in your system for this period of time, before being flushed out.

With this type of half life of GW 50156, your body can feel the effects of this synthetic compound for this period of time. However, alongside this half life there are some side effects to look out for. But first, let’s talk about the potential benefits of Cardarine.

Benefits of Cardarine GW 501516?

Those looking to burn fat and maintain lean muscle gains often look to drugs such as Cardarine GW 501516 for these elements. But how else could GW 50156 help? Here’s what we know about it so far…

  • It may have the potential to reduce LDL (the ‘bad’) cholesterol, therefore supporting heart health
  • By activating the PPARδ receptor, Cardarine GW 501516 could, in turn, produce anti-inflammatory effects, reducing oxidative damage to blood vessels and tissues
  • GW 501516 has the ability to increase endurance, helping its user to stay fit and increase their fitness levels
  • It has the potential to increase lean muscle mass, however, many users report these results are best seen when stacking Cardarine GW 501516 with a SARM (selective androgen receptor modulator)
  • By enhancing nitric oxide levels in the arteries, recovery times may be improved
  • Cardarine GW 501516 tries to suppress glucose metabolism in the liver, working to switch energy sources from glucose to fatty acids
  • In most cases, there is no need for post cycle therapy (PCT), as not all users experience hormone suppression while taking Cardarine. It can also be used during post cycle therapy after a SARM cycle, to avoid fat gain

With many users choosing GW 501516 for increased endurance, many report experiencing even better endurance week after week, especially during running.

Cardarine and reducing body fat

Used primarily for fat burning, Cardarine is incredibly popular during cutting cycles. This enables users to reduce their body fat % and uncover lean muscle below. Put simply, Cardarine fat burner works in two different ways:

  1. It works to increase oxidative capacity within muscles (giving you the power to burn calories, therefore burn fat)
  2. Cardarine GW 501516 works to suppress glucose metabolism – switching the body’s energy source from glucose to fat, supporting fat burning

Improved cardiovascular health

While you may not immediately connect the dots, GW 501516 was first researched and developed in relation to cardiovascular diseases.

During animal studies and testing (on rats), it showed to have a positive impact on cardiovascular health, even at a low dosage. Cardarine GW 501516 works to clear blood vessels, lowering the risk of heart attack and other cardiovascular diseases.

Also Read: Looking for 100% Natural Supplements to Rocket Your Workouts?

Although difficult to find well established human trials, there have been a number of trials carried out, in 2007 and 2012. Unfortunately, there isn’t enough body fat % data gathered from these trials for a clear result in this area.

However, the trials did reveal positive changes to HDL, cholesterol and triglycerides.

Muscle mass growth/preservation

While primarily used to help lose fat, GW 501516 has shown to have muscle-building benefits (according to this study in mice) – driving the development of muscle fibers and improved endurance. While helping to reduce a high body fat percentage, it may also work to preserve muscle mass.

Improved blood flow

As well as helping users to preserve lean muscle and burn fat, GW 501516 has also shown to boost blood flow by improving blood vessels, blood pressure and reducing inflammation. The latter may mean that you’ll be able to recover faster after your workout.

Our conclusion

Put simply, many a Cardarine review have supported Cardarine’s abilities to enhance workout performance, increasing endurance while helping the user to reduce high body fat percentage. But what about side effects?

Are there any side effects of Cardarine GW 501516?

Known as a research chemical, there is little true research into Cardarine GW 501516. This means that reported side effects are typically reported by users – but this should still give you a good idea of what to expect during Cardarine cycles.

Meanwhile, in one study of 13 men with high belly fat and bad cholesterol levels, Cardarine GW 501516 showed to decrease triglycerides, fatty acids and VLDL proteins.

In an animal study, despite results showing it improved blood circulation in the brain, reducing oxidative damage and stress, it also increased IL-6, which can cause brain cell damage.

Let’s break down the side effects of Cardarine a little more, and investigate why it isn’t deemed fit for human consumption.

Liver damage

The trouble with synthetic drugs like Cardarine GW 501516 is that they need to filter through the liver. But it can be a lot for the liver to manage – especially since the liver is the most critical organ involved in the burning, release, and storage of fat in the body.

However, there are mixed opinions on Cardarine consumption and its impact on the liver. During initial animal and cell studies, GW 501516 showed to potentially have a positive impact on liver health…

But sadly, it was soon discovered that GW 501516 caused the death of liver cells as well as fibrosis or liver damage. This means that even at ow doses, Cardarine can be dangerous to the liver.

Kidney disease and heart health

At small doses, Cardarine consumption has shown to decrease tissue damage and inflammation in the arteries and blood vessels. However, this was during research/trials in mice!

Although, these findings led them to further investigate a link between Cardarine GW 501516 and heart disease.

While overall, GW 501516 may benefit someone with heart disease, it could be considered too much for a healthy individual – or one who had a propensity to develop cancer.

In addition, Cardarine consumption and its impact on kidney disease showed it could potentially lower kidney inflammation and the activity of genes that indicate the presence of kidney disease.

Is Cardarine legal?

Cardarine GW 501516 is currently considered an illegal substance that is unfit for human consumption. It is also banned by the World Anti Doping Agency, so you’ll be unable to compete while taking Cardarine.

Put simply, there is certainly room for further studies into this research compound!

Many users of Cardarine have claimed accelerated fat loss, but with side effects including liver damage, is it worth it?

If you’re looking to buy Cardarine, opting for a safer, legal alternative such as ENDURO LEAN can help deliver the benefits and results – without the side effects.

Why risk it? Opt for a safe and legal alternative to GW 501516

If you spend some time reading a Cardarine review in great detail, you’ll start to see how dangerous some of its side effects can really be. We’re not so sure that the potential benefits outweigh the side effects.

With very little human research/trials, we’re pretty much in the dark as to how it may affect the body long term.

Why not opt for a 100% legal, safe alternative? We create ENDURO LEAN for this very reason. It’ll launch your body into fat burning beast mode, with zero side effects.

Why mess around with SARMs and other synthetic drugs like GW 501516, when you can safely and naturally reduce your body fat AND preserve that shredded lean muscle mass?

With every cycle you will recognise peak results in:

  • Enhanced muscle endurance
  • Lean muscle gains
  • Accelerated fat loss
  • Increased energy levels
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