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What is Tesamorelin and are there any side effects?

It’s not uncommon to get muscle envy when some hench dude walks into the gym. But more often than not, that muscle isn’t quite as natural as it may appear…

Yep! the chances are, he could be using something called Tesamorelin. Today I’m gonna be taking a closer look at Tesamorelin, covering everything from how it works, its potential benefits and whether there are any side effects involved.

Put simply, Tesamorelin is a peptide, but if you’re unsure what that really means, hold tight, we’re about to explain it all below.

What is a peptide?

Somewhat similar to popular anabolic steroids, peptides are often used to enhance performance. In recent years, Tesamorelin and other drugs have risen in popularity, and are often considered a more ‘natural’ alternative to anabolics.

After a quick search online or a chat with some dude down the gym, you’ll undoubtedly hear about the many ‘benefits’ of Tesamorelin – including their ability to increase growth hormone levels, boost muscle mass and encourage fat loss.

What is Tesamorelin?

While there’s often confusion between anabolic steroids, SARMs and peptides, Tesamorelin is actually a peptide known for triggering the secretion of growth hormone. Carefully designed to mimic growth hormone releasing hormone (GHRH), this peptide is highly sought after by bodybuilders.

However, it’s important to remember that GHRH is one of the thousands of peptides that naturally occur in our bodies, playing a key role in regulating bodily function. GHRH is at its highest during puberty, however, its production can reduce as we get older.

While you may think that GHRH deficiency is what’s holding you back in the gym, it’s unlikely that you’re suffering from growth hormone deficiency. But, that doesn’t mean, however, that a boost in growth hormone won’t benefit your gains.


Is Tesamorelin a growth hormone?

Technically, Tesamorelin is a growth hormone releasing analog that works to increase insulin like growth factor 1 levels. It works by stimulating the GHRH receptors, reducing visceral fat – making it incredibly popular with bodybuilders looking to get shredded.

Furthermore, the main focus of clinical trials has been its use for HIV infected patients.

What was Tesamorelin originally intended for?

Developed to treat growth hormone deficiency, Tesamorelin has typically been prescribed to HIV infected patients. Of course, it hasn’t taken long for its benefits to be picked up by the bodybuilding community – especially since it can have powerful effects on muscle growth and recovery times.

One of the most common reasons that users look to anabolic steroids, SARMs and peptides such as Tesamorelin is to enable them to break through a plateau. Often, burning stubborn fat and building muscle can feel like an uphill battle. This is where Tesamorelin often comes into play, since many of us want abs of steel and struggle with abdominal fat accumulation.

How does Tesamorelin work?

A type of synthetic peptide, Tesamorelin is comprised of 44 amino acids – analogous to the growth hormone-releasing hormone (GHRH). It works to stimulate the pituitary gland in releasing GHRH.

Once released, it is known to promote lipolysis – the term coined for the process in which lipids and triglycerides are broken down.

Why do most people use Tesamorelin?

One of the key benefits of Tesamorelin, according to users, is its ability to help reduce excess abdominal fat. So much so, that some users have reported between a 15 and 17% drop in around 20 weeks. However, these studies have been carried out with those that have HIV-associated lipodystrophy.

Is Tesamorelin suitable for women?

If you’re really considering Tesamorelin, you’ll be pleased to hear that it can be used by both men and women. However, it is not suitable for pregnant women, or those that are planning to become pregnant, nor is it suitable for those on diabetes medication. 

Human growth hormone explained

Although many of us believe we need to supplement HGH through synthetic injections, or seek the help of anabolic steroids, human growth hormone is actually produced naturally in our bodies by the pituitary gland. It’s actually incredibly important for growth, cell regeneration and cell production, as well as the building and repair of healthy tissues.

As we get older, our natural supplies can start to reduce slightly. However, it is unlikely that you have a true HGH deficiency, as this is typically noted in childhood.


Tesamorelin benefits

The primary benefit of Tesamorelin is to increase serum levels of growth hormone (GH). However, an added ‘benefit’ of Tesamorelin that is widely recognized is its power to burn away abdominal fat accumulation.

To sum up the benefits, here’s what many users report:

  • Increase GH levels
  • Fat loss, especially around the stomach
  • Increased muscle mass
  • Improved cognition
  • Reduced risk of cardiac disease – due to its power to burn fat/reduce weight 

Should you stack Tesamorelin?

Is Tesamorelin safe to stack? Unfortunately, there is little research to suggest that Tesamorelin is safe to stack. Much like the discussion of Tesamorelin vs Ipamorelin, there is little to no research on their safety for bodybuilding, stacked or not.

If you’re unsure of a drug’s safety, it’s best avoided altogether.

What about other peptides?

Tesamorelin vs Ipamorelin are the two peptides most frequently put up against one another. However, the main difference between the two is the amount of clinical, human-based research. At present, Ipamorelin is yet to undergo this type of research.

However, the effects of these peptides are quite similar.

What about Sermorelin?

Sermorelin has a short half life in comparison, with Tesamorelin also stimulating the pulsatile release of GH from the somatotrophic cells.

Where can you buy Tesamorelin?

Although you may be able to buy Tesamorelin online, we highly recommend purchasing it in this way. If you’re seeking a legal prescription, you will find that doctors will only prescribe it to HIV infected patients, suffering from HIV-associated lipodystrophy.

Tesamorelin dosage

When it comes to hitting the right Tesamorelin dosage, it can be tricky knowing the exact amount. However, put simply, it depends on your goals.

Either way, sticking needles anywhere isn’t fun, nor recommended.

Tesamorelin dosage for fat loss

If you’re on a mission to burn through excess abdominal fat, here’s the typical Tesamorelin dosage when prescribed for lipodystrophy:

  • 2mg
  • One injection per day
  • Done at night, at least 90 minutes after eating

If your aim is bodybuilding, here’s what users report as the optimal dosage:

  • 1mg of Tesamorelin
  • One injection per day
  • Done at night, at least 90 minutes after eating
  • 5 days on, 2 off

What about cognition?

Studies have shown that the following dose of Tesamorelin has proved successful for cognition:

  • 1mg of Tesamorelin
  • One injection per day
  • Done at night, 30 mins before bed
  • 5 days on, 2 off
  • For 20 weeks

In addition, Tesamorelin peptide is often used for anti-aging, as well as injury recovery. By boosting human growth hormone, this popular peptide can improve your skin and give the appearance of being more youthful.

If you do choose to use Tesamorelin peptide, here are our top tips for preparation and usage:

  • Always wash your hands before/after
  • Reconstitute the Tesamorelin dosage
  • Check for any discoloration or particles
  • Clean the injection site
  • Inject under the skin
  • Change the injection site for each injection to avoid over-injection
  • Always take it at night – This is because human growth hormone is naturally at its highest when you’re asleep
  • Remember to always take at least 90 mins after eating – This is due to the potential for food to disrupt how Tesamorelin is absorbed
  • Get into a good cycle routine to give your body a break

How long does it take for Tesamorelin peptide to kick in?

According to trials, research suggests that you will start to feel/notice its effects after around three months.

Is Tesamorelin peptide technically a steroid?

No, it is a peptide.

Tesamorelin side effects

Although Tesamorelin may have been developed for HIV infected patients, it comes as no surprise that it has found its way into the bodybuilding community. But is it worth it?

We’ve done some digging at the potential side effects of Tesamorelin, as reported by users:

  • Injection site reactions
  • Sweating
  • Muscle aches
  • Vomiting
  • Diarrhea
  • Frequent urination
  • Chest pain
  • A feeling of fatigue
  • Increased hunger

If you notice any extreme side effects, stop your Tesamorelin cycle immediately.

It’s important to rotate the injection site, to avoid over-injecting in the same place.

Pros and cons of Tesamorelin peptide


  • It triggers the release of GH naturally
  • Helps manage HIV-associated lipodystrophy
  • Releases IGF-1 without affecting blood sugar levels


  • Needs to be taken continuously or visceral adipose tissue can start to accumulate again
  • Might increase the risk of cardiovascular diseases

Is Tesamorelin peptide legal?

Is it legal to buy Tesamorelin peptide? Well, this may depend on where you are. In most countries, it is legal to buy. However, the preferred way to gain access to this popular peptide would be via a prescription.


The bottom line

There’s no denying it, Tesamorelin peptide wasn’t designed for dudes to cut fat and build muscle in the gym. If you ask us, the side effects aren’t worth it – especially with little research in regards to its use for bodybuilding and reducing body fat.

As a synthetic growth hormone releasing factor analog, the benefits may be tempting, but there is another way to burn through fat – with zero side effects…


Stop wasting time during your cut, chasing the idea of utilizing dodgy steroids, SARMs and peptides – some of which can be incredibly dangerous and/or illegal.

There is another way. We create the super-strength Cutting Stack to minimize the time you spend cutting and maximize the percentage of fat you’re shredding. That’s the only way to go, bro. Stop compromising your cut – and your results.

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